Chapter C: F. Dawson, in investigating a wasting disease of well fed Brahma (12)

_Symptoms._ The animal is at first dull and sluggish, with drooping head, lusterless eyes, staring coat, normal respiration and temperature, pulse often about 60 per minute, relaxed bowels and marked diminution of the milk secretion. The milk acquires a bitter taste and unpleasant odor. The pulse is usually full and soft, and the eyeballs may bulge visibly out of the sockets. The diarrhœa tends to encrease, the stools becoming liquid and black, yet in exceptional cases the bowels are confined for the first four or five days, or even permanently, appearing to be completely paretic. By the end of a week the abdomen becomes full and pendent with hollow flanks (pot bellied), or even rounded and tense, while manipulation and percussion show an abundant exudation into the peritoneal cavity. The pulse encreases in frequency (80) but the temperature is not elevated unless there is concurrent sepsis (Johnston). Thayer quotes an advanced case with a temperature of 105° F. He also notes obstinate standing, trembling of the muscles of the hind limbs, and complete suppression of appetite and milk secretion.

The disease is essentially chronic, often lasting a number of months. Many cases are doubtless slightly affected before external symptoms are manifested.

_Lesions._ If the disease has resulted in death there is usually marked emaciation, yet the abdomen is distended by accumulation of a clear yellowish fluid. From six to nine or more gallons may be present. The fat of the omentum, mesentery and sublumbar region has disappeared and the connective tissue is distended by a clear, amber-colored, watery fluid. The liver is the seat of marked changes. In the early stages it is congested and the gall ducts and bladder are filled to repletion with a thick, dark colored bile, which is further present in abundance in the intestines. In these early stages Johnston found cloudy swelling and opacity of the hepatic cells; somewhat later they had undergone distinct fatty degeneration. In the advanced stages, however, in animals that had been ill for two or three months, there was distinct fibrous degeneration, and compression and disappearance of the normal liver cells, in other words, a condition of marked cirrhosis, the result doubtless of the early congestion.

Johnston further notes the distension of the submucosa of the fourth stomach at intervals by a clear, viscid, liquid exudate, so that rounded swellings appear on the surface, and in some instances, after a month’s illness, distinct ulcers are shown upon the mucosa.

The lungs, pleuræ, pericardium and nervous system, are usually normal, unless in case of septic complication when petechiæ and circumscribed blood extravasations may be seen.

_Prevention._ The Canadian government has gone to great expense in buying and slaughtering the diseased cattle with no very evident good result. McEachran suggested the feeding of oil cake and other albuminoid and oleaginous food to counteract the alleged malnutrition, but Johnston’s cases in over fed animals show that something more is demanded. Another suggestion has been made to the effect that cattle should be exterminated in the affected counties to remove the material necessary for the maintenance of the poison. But, if the poison is produced by a cryptogam growing on the vegetation, as seems not improbable, it would be likely to extend all the same in the absence of cattle. In such a case the true course is to study the nature of the organism, and the phanerogam on which it grows, when it might become possible either to exterminate the flowering plant which acts as a host for the offending organism, or to spray it with an effective fungicide and thus reach the object in another way.

INFECTIVE GASTRO-ENTERITIS AND PNEUMONIA IN THE NEW BORN; WHITE SCOUR.

In treating of this disease in Vol. II, page 141–2, the work of Jensen, Perroncito and Nikolski is quoted, with the remark that “_it is premature to specify any particular microbe as the sole cause of the affection_.” Since the publication of that volume, Nocard, investigating in Ireland a very prevalent and fatal affection of new born calves, which proved fatal by “white scour” a few days after birth, or by pneumonia one or two weeks later, identified as the pathogenic agent a small, nonmotile, ovoid bacterium, taking the polar aniline stain, bleaching in Gram’s solution, failing to liquefy gelatine, or to form indol or to grow on potato. In other words it shows the general characters of the colon group of bacteria, causative of hæmorrhagic septicæmia, and classed as _pasteurellas_ by Trevisan and Lignieres. This is not found in blood and lesions in all subjects, but is usually present in pure culture in the most acute, fatal cases. Its occasional absence later in the disease is explained, according to Lignieres, by the power possessed by these germs of robbing the healthy tissues of their power of resistance and laying them open to the attacks of other microörganisms which are usually present in abundance, but are harmless to the healthy tissues in the absence of the Pasteurella. As the disease advances, therefore, the primary pathogenic agent (the Pasteurella) is crowded out by the active growth of other bacteria, which accordingly are found in complex cultures and in great variety. In his first observations on the victims of the _white scour_, Nocard found only these complex cultures, of which no one variety, isolated in pure cultures _in vitro_, and inoculated, proved capable of causing the disease. Later he found the Pasteurella (cocco-bacillus) in impure cultures from the diseased femoro-tibial joint of one of the subjects of the affection, and the pure cultures obtained from this were virulently infective.

A few drops injected into the peritoneum of a Guinea pig, or veins of a rabbit, killed in six to eighteen hours with the lesions of hæmorrhagic septicæmia which characterize the most acute cases of _white scour_. The blood and viscera swarmed with the microbe.

A calf one day old had 3cc. of the culture injected into the jugular, the temperature rose in six hours, and in twenty hours the subject lay with sunken eye, retracted abdomen, a temperature of 95° F., and having the bed saturated with a yellowish, fœtid, fæcal liquid. Death took place 30.5 hours after the injection and all the lesions of acute _white scour_ were met with.

A second calf four weeks old, which had already suffered from _white scour_ and recovered, had an injection into the jugular of 10cc. of the same culture. In six hours he suffered a slight rise of temperature, was dull and breathed short, but in twenty hours he was completely recovered, full of life and appetite.

In other casual and experimental cases, Nocard found that when death occurred within one or two days the symptoms and lesions were mainly those of hæmorrhagic septicæmia and _white scour_, whereas if the calf survived several days, the impaired resistance of the tissues invited the invasion of a variety of other germs from the intestines, and infective inflammation of the lungs, joints and other organs were brought about by such secondary invasions.

An important question is as to the direct source of the primary (Pasteurella) infection. The concentration of the acute cases on the alimentary canal would strongly suggest infection through the food which in this case means the milk. But careful bacteriological examination of the milk of the dam of a calf that had just died of _white scour_, and of other milk secured with careful precautions from cows in an infected stable, showed that both were clear of the germ. Inoculations and culture experiments were equally fruitless.

This does not exclude the probability of the contamination of the milk, obtained under ordinary conditions, with the germ contained in the floating barn dust, or that which was adherent to the teat and udder.

Another suggestion is that the infection is derived from the infected womb prior to birth, but as Nocard justly says, if this were so, abortions would be much more prevalent, as the rapidly fatal issue of the disease would determine the prompt death of the fœtus and its expulsion. The coincidence of abortion and _white scour_ in a herd is not uncommon, and in such cases intrauterine infection of the fœtus is not improbable, but in the great majority of cases no such coincidence exists.

We are thus thrown back on infection through the raw surface of the ruptured umbilical cord, as the rule in such cases. It may be that this has come from the vagina or vulva, but in the great majority of cases it is manifestly derived from the infecting bowel dejections and the dust caused by their desiccation. The extraordinarily rapid progress and fatal result of the acute disease, and the early abundance of the germ in the blood and liver, suggest that the microbe traverses the umbilical vein to the liver, and finding a congenial home in the blood is quickly distributed through the entire body.

_Prevention_ must be based on the destruction and exclusion of the microbe.

A thorough disinfection of the stable with mercuric chloride has not given us uniformly satisfactory results, even when the building has been kept apparently almost immaculately clean. This argues a renewed infection through the fæces of the cows, yet it is the rule that the removal of the cow to a new or unused stable a few days before calving will usually secure the immunity of the calf. This method is however open to the objection that the removal to such calving stable of a succession of cows coming from infected premises soon introduces the infection and renders it as dangerous as the place they have left. To carry out such a plan therefore a number of new stables or sheds must be provided to be used in succession, as they become one by one contaminated.

Nocard confines his instructions to the antisepsis of parturition and of the offspring:

“Cows ready to calve should be provided with dry and clean bedding until after the birth of the calf.”

“As soon as labor sets in, the vulva, anus and perineum should be cleaned with a tepid solution of lysol in rain water: 20 grammes of lysol to each litre of water. The vagina should also be cleansed by injecting with a large syringe a great quantity of the same solution tepid.”

“As far as possible the calf should be received on a clean cloth or on a thick fresh bedding, not soiled by urine or fæces.”

“The cord should be tied immediately after birth, with a ligature kept in a lysol solution, and the cord amputated below the ligature.”

“The stump of the cord and the umbilicus should be washed with the following solution:

Rain water 1 litre.
Iodine crystals 2 grammes.
Potassium iodide 2 grammes.”

“The disinfection of the umbilicus and cord should be completed by coating them with

Methylic alcohol 1 litre.
Iodine crystals 2 grammes.”

“When the alcohol has evaporated the cord and umbilicus should be covered with a thick layer of iodine collodion (1 per cent.) applied with a brush. When the collodion has dried the calf may be left to the care of the dam.”

This treatment may be changed by substituting other antiseptics, and by prompt separation of the calf from the infected stable and dam. It is also important to disinfect thoroughly and often the cow stable and calf-pen, to remove instantly any calf that may show signs of scouring or general disorder and to purify its pen and leave it unoccupied for some time.

It should be added that the period of danger is in the first few days after birth, and while the umbilicus is still unhealed. If scouring should come on later it is much more amenable to treatment. A seclusion of the calf for one week is usually sufficient to secure its escape.

NOTE ON BACTERIOLOGY AND TREATMENT OF HÆMOGLOBINÆMIA IN THE HORSE.

As supplementary to the article on hæmoglobinæmia (vol. II., page 437) the later bacteriological investigations of Lignieres must be noted. A superb Percheron, after two days of idleness, went to work at 10 P. M., was attacked at 1 A. M. and died at 3 P. M. Inoculations from blood, spleen, liver, kidney, bone marrow, myelon and subarachnoid fluid from the loins to the bulb proved sterile, excepting that made from the subarachnoid liquid on a level with the bulb, which yielded a rich culture of a streptococcus that appeared to the eye as small granules. It proved ærobic and anærobic, stained well with Gram’s (I) solution, coagulated milk, acidified the culture, formed small, round, grayish white colonies on peptonized gelatine, without liquefying, failed to propagate on potatoes, but grew well in serum and bouillon.

Two or three drops proved fatal to mice, producing, when thrown into the peritoneum a highly acute parenchymatous nephritis with bloody urine. Very few microbes were found in the kidney. There was loss of control of the hind limbs and extreme nervous irritability.

Intravenous injection of 300cc. of the culture in a powerful stallion produced hyperthermia, 102° F. on the second day, 104° on the third, 105° on the fourth, on the sixth day he became paraplegic and died on the seventh.

A second horse, which received 150cc., was sick for several days, but without paraplegia, then appeared to recover, but three weeks after he became paraplegic with albuminous urine and died next day.

In neither of the horses was the urine sanguineous.

Carnivora, swine, ruminants and birds proved insusceptible. The guinea pig succumbed to intraperitoneal inoculation, and the rabbit to intravenous.

It is to be noted that hæmoglobinuria was lacking in both experimental equine cases, and though this may be so in mild casual cases, the same is not true of violent and fatal ones. It is, therefore, evident that further research is necessary in this direction.

Accepting the conclusions reached by Lignieres, we are still debarred from entering the affection in the list of animal plagues proper, to be met by official restrictions. The streptococcus may be an essential condition in each case of the disease, or it may be one of several microbes that may act in the causation, yet the microbe in ordinary doses as accidentally introduced, does not prove pathogenic excepting in the presence of concurrent conditions of high feeding and condition, work, interrupted by one or more days of absolute idleness, and the resumption of exercise. The presence of the microbe is not enough to cause the disease in the horse in continuous work, nor in that which is kept in the stable all the time, nor even in the horse that has worked steadily and then stood idle for a day, until he again goes to work. One animal or a few only out of a stable, are attacked, and there is no such active extension from animal to animal in the vicinity that characterizes the plagues proper.

The _prevention_ of the disease, therefore, must be sought along the lines previously laid down and well understood, in the avoidance of sudden plethora, of transient idleness during a period of high condition and steady work, and of gradual restoration to work after such period of rest. Similarly the _treatment_ by rest, depletion, diluents, evacuants, and nerve sedatives is still in order. A new importance, however, attaches to the use of nerve sedatives and antiseptics, as calculated to prove a check on the disorder of the nervous structure and functions and on the active proliferation of the microbe.

The presence of the streptococcus may also contribute, along with the permanent changes in the nerve structure, in predisposing to relapses or second attacks, which are so common unless the animal which has once suffered is subjected to very special care.

As a fruit of the research by Lignieres, W. A. McClanahan, Redding, Ia., essayed internal antisepsis by ½ oz. doses of potassium iodide. In three severe cases relief was obtained in 15 to 20 minutes and an early and complete convalescence followed. In the hands of J. H. Kelly of New Haven, Conn., and T. S. Childs of Saratoga, N. Y., it seemed to prove equally successful, the first meeting with almost invariable success, and the latter reporting a series of 10 successive cases, several of them severe, which all recovered in from 1 to 5 days. The only untoward result was an open knee joint in one subject, the result of bruises sustained before Dr. Childs arrived. His treatment was ½ oz. of the iodide at once, and 1 to 2 drs. every hour or second hour, according to the size of the animal and the severity of the case.

In other hands this medication has been less successful, which may well be explained by the violence of the attacks, and the lack of absorption from the inactive stomach. Unless it passed on to the duodenum, it would be utterly useless, and hence the exhibition by the rectum or subcutem might be tried. The parallelism of the treatment of the two diseases of the plethoric and possibly infected subject,—parturient paresis and hæmoglobinæmia,—is striking, and it does not seem that the iodide treatment should be abandoned because of a few unsuccessful cases. Whether the iodide acts mainly as a microbicide, a chemical antidote to toxins, an eliminant, or a nerve sedative, or in two or more of these modes, is unknown, but it would be rational to expect good results along one or more of these lines. Iodide treatment should supplement, not supersede, the methods formerly in use.

INFECTIVE ULCERATION OF ANUS AND VULVA IN CATTLE.

This curious affection is recorded as having prevailed in the winter of 1897–8 in different localities in Iowa, Missouri, Kansas and Nebraska. In 1900 and 1901 it was again reported in different parts of Iowa.

_Causation._ No bacteriology of the disease has been given, and its appearance in isolated herds which had no known communication with other herds, and even in the young cattle on a farm to the exclusion of the older ones, seems to suggest an enzoötic origin, perhaps in food or water, or in some toxin determined by a fermentation of organic matter out of the body.

On the Rodkey farm at Blue Rapids, Marshall county, Kan., eight heifers from ten to fourteen months old, suffered, while the seventeen steers of the same age and the milch cows escaped. (Steddom). Near Shelby, Ia., a bull, from a healthy herd, broke into an affected herd and served cows there, and was afterward returned to his own herd and served cows there, but did not communicate the disease. (S. T. Miller). No case is recorded to show that any bull serving affected cows or heifers contracted ulcer or other disease of sheath or penis.

In one herd near Shelby, Ia., nineteen head of cows and heifers suffered, while the four steers in the herd escaped. In another herd of twenty-six head, in the same district, the four cows and eight of the twenty-two steers suffered. It is not, therefore, confined to the females. (S. T. Miller).

In all cases the disease appeared in the cooler months, from October to April inclusive, and while the cattle were secluded in muddy yards.

In different cases they occupied the yards in common with swine which were charged with wounding the vulva, until the general character of the outbreak forbade this conclusion. At Blue Rapids it was sixty-two days after they had been yarded with the hogs before the disease was observed.

In this case the lot was small, poorly drained and very muddy most of the time. Calves and hogs drank from the same troughs until the disease appeared. The water supplied to the calves and hogs was from a well sixteen feet deep. The cows, which escaped, were supplied with water from the Blue River.

Cows, heifers and steers were fed on a ration of shelled corn 6 parts, rye 1 part, oats 1 part, and had an abundance of fodder, consisting of prairie hay and millet in equal parts. They were in good condition, some of them fat, and nearly all dehorned. A second herd had shelled corn, kafir corn and cane, with water from a shallow well, and all (cows and heifers) suffered.

As showing the localized nature of the cause, C. Muller adduces the case near Ottumwa, Ia., in which a herd of 30 calves were attacked, and sold out, the owner filling the same yard a few days later with 30 more bought in the surrounding country, and which he put on the same rations. In about 10 days the disease appeared in the second lot.

On the Rice farm, Blue Rapids, were 60 yearling heifers, bought in Kansas City, and two home cows. In the first week after arrival 5 heifers suffered, in the second week 20, in the third week 40, and in the fourth week all the 60. The two cows mingling with them were only slightly affected.

In the Rodkey farm, Blue Rapids, cases, all of the young cattle (which alone suffered) had been raised on the farm and had not been exposed to outside cattle.

_Symptoms._ “The ulcer, in almost every case, started as a mere abrasion, the size of a pinhead, usually on the inner surface of the labia, near the border of the inferior commissure, gradually eating its way through until it appeared as a much larger denuded surface on the outside” (C. Miller). S. T. Miller says: “The first noticeable symptom was serous exudate, rapidly forming into a brown scab, under which was very fœtid pus, with extensive inflammation. The affection usually occurred on the lower portion of the lips of the vulva, in heifers and cows, and in steers around the anus or root of the tail. The scabs which formed seemed to spread very rapidly, destroying more and more of the underlying tissue and forming a thicker and thicker scab. The scab, if pulled off, would expose a raw surface which would bleed very readily. In a short time a new scab would be formed.”

Steddom says: “The vulvar lips thickened and continued to discharge for four or five days. In the meantime certain pustules appeared, 0.1 to 2.5 centimeters in diameter. About the fifth day these ruptured and discharged yellowish pus.” The mucous membranes of the vulva and vagina were dry and slightly congested. The ulcers were covered with brown leathery scabs, which adhered tenaciously and when detached left an angry, red, purulent, granular, elevated and pitted surface. In some of the more severe cases, one or both lips of the vulva had sloughed off, and the sore had extended 10 to 15 centimeters on the skin of the escutcheon. The pus from this sore did not corrode the adjacent skin.

The more severe cases showed loss of appetite, constipation, hurried breathing, tucking up of the abdomen, with general dulness and dejection, and great tenderness of the affected skin with stiff, straddling gait.

_Pathology._ This is very obscure. The primary cause of the sores is not evident, though their occurrence on the anus and vulva only, and especially on the latter would suggest an elective affinity of the poison (microbian or chemical) for these structures and their products. If we assume a pathogenic microbe in the fæces, the question arises as to the cause of the habitual immunity of the steer, and of the margin of the anus in the majority of the affected heifers. The susceptibility of heifers rather than cows may imply a previous exposure and acquired immunity on the part of the mature animal.

Again if we suspect the existence of a necrobiotic agent of organic origin (like ergotin, secalin, sphacelin) we must assume a superadded microbian infection, implanted in the primary sore and rapidly extending it. The prompt recovery under antiseptic treatment shows that no mere chemical poison maintains the destructive process, for it is manifestly the microbicide which puts a prompt limit to the disease, and under such treatment no sphacelating agent in the blood or tissues keeps up the advance of the ulceration or prevents healing.

_Treatment._ The ulcers healed rapidly under cleanliness and antiseptic applications. The tail, anus, and vulva were washed with tepid water, and then dressed with a solution of creolin (5:100), or carbolic acid (3:100), or mercuric chloride (1:500 or 1000). The ulcers were touched with a pencil of silver nitrate. S. T. Miller followed the sublimate lotion by the subjoined ointment: iodoform 20 grains, eucalyptol 40 minims, phenic acid 20 minims, petrolatum enough to make 2 oz. C. Miller in addition to the carbolic acid lotion applied the common white lotion (zinc sulphate 1 oz., lead acetate 1 oz., water 1 qt.) and used silver nitrate on the ulcers. Four dressings on four successive days were given and in the milder cases healing was completed in 10 or 12 days.

NOTE ON GOOSE SEPTICÆMIA.

As these pages are going through the press, Cooper Curtice’s bulletin on _Goose Septicæmia_ comes to hand.

This affection in 1900 caused a loss of 3,200 geese in July and August to Mr. Cornell, a Rhode Island owner. Mr. Snell lost 500.

_Bacteriology._ The blood and tissues swarmed with a minute bacillus having the general morphological staining and biological characters of that of chicken cholera and rabbit septicæmia. It differed from these in the failure to infect chickens, whether inoculated or fed to them. It proved deadly to geese, ducks, pigeons, rabbits, mice, and more slowly to Guinea pigs. Geese were infected by inoculation or feeding of the germs, ducks from inoculation only.

_Symptoms._ The geese were often found dead, and even in those noticed ill, death supervened so early that no very diagnostic symptoms were made out. The affected geese moved tardily and unsteadily, and failed to keep with the remainder of the flock. Some burrowed the head in the dirt and twisted it around, indicating, it was supposed, spasms of the throat. Some were seized with the death agony in a few minutes; in others the illness lasted for hours, and from experimental cases it was concluded that the period from infection to death, in the majority of cases, did not exceed thirty-six hours. Some were believed to merge into a chronic condition, but the owner thought that none recovered. No diarrhœa is noted.

_Lesions._ The head was the seat of marked venous and capillary congestion, suggesting asphyxia. The bill and throat contained a large quantity of tenacious mucus, which was especially viscid in the nose. Extravasated blood in abundance was present in the gastro-intestinal mucosa and contents, much of it more or less digested. At some points there was abundant mucous exudate; at others the folds were only marked by punctiform petechiæ, or by bloody patches formed by their coalescence. The cæca were usually normal.

The liver showed numerous punctiform extravasations and yellow patches of necrosis extending more or less deeply into the hepatic tissue. Other congestions were seen in individual cases, implicating, in one instance, the heart and pericardium, and in another the lungs. Petechiæ were frequent on the pericardium and other mucosæ. The blood was usually black, tarry, and with little disposition to brighten on exposure to the air.

_Diagnosis._ It is recognized as an infection of domestic water fowl by its attacking the larger proportion of that class of animals exposed to it. It is supposed that those which escape do so because of immunity due to a previous attack, or by reason of the absence of any wound of the mouth, throat or stomach by which the germ might enter. It is distinguished from _fowl_ (_chicken_) _cholera_ by the immunity of the chicken in this case. It is differentiated from Klein’s _diarrhœal enteritis_ of fowls, by the fact that neither pigeon nor rabbit is immune. From the _duck cholera_ of Cornil and Loupet, it is diagnosed by the immunity of the chicken only, while the rodents and pigeon suffer.

The germ is manifestly one of the family of bacilli of the colon group, found in the different septicæmias, but sufficiently distinctive from these other forms, in its pathogenesis, to demand a separate place in connection with sanitary work.

_Treatment_ is hopeless from our present point of view.

_Prevention_ is the rational resort. In the case of those raising geese from the egg, it is imperative to abandon, for the season at least, any pastures that may have become contaminated. It would be better still to subject such pastures to cultivated crops for one or two years. The pens should be thoroughly disinfected or abandoned and burned. Mr. Cornell used his infected pens for ducks without evil result. The drainage from infected pastures or pens must be guarded against, no geese nor ducks being allowed on land through which, or on which it passes, and no water receiving such drainage being employed for geese. In the case of feeders or handlers of geese who buy the birds in large numbers from many sources, a subsidiary quarantine should be constantly maintained, by enclosing the birds in as small groups as possible in separate pens, so that infection in one pen will not endanger the whole flock. When infection is shown in a pen, the diseased birds should be at once destroyed and burned, the pen thoroughly disinfected, and the other birds returned, or better, divided up into still smaller lots, so that infection showing in one of these will not endanger the great number taken from the original infected pen. The utmost care should be taken to maintain the most perfect cleanliness in the pens of exposed and suspected geese, and to sprinkle the floors and manure liberally with an antiseptic, such as a solution of sulphuric acid in water (2:100), or of phenic acid (3:100), or of a combination of the two. This will do much to prevent the hatching of flies to act as infection-bearers, and if these can be further excluded by screens the condition will be still more satisfactory. Vermin of all kinds should be excluded and whenever possible, separate feeders and attendants should be furnished for the suspected geese, and those that have not been exposed.

NOTE ON HÆMORRHAGIC SEPTICÆMIA IN CHICKENS AND TURKEYS.

Lucet describes a septicæmia of chickens and turkeys accompanied by dysenteric discharges. The microbe resembles the bacillus gallinarum of Klein (see Vol. II, p. 254), even in the immunity of pigeons and rabbits when injected subcutem. Rabbits, however, suffer when injected intravenously. The probability is that this bacillus is identical with that of Klein. Yet in this whole class of microbes of the colon group, variations, apparently superinduced by environment, appear to result at times in a deadly pathogenesis for different genera, and epizoötics differing from each other.

DISEASES, INFECTIVE OR TOXIC, TREATED IN EARLIER VOLUMES.

=Catarrh; Malignant of Cattle.= Vol. I, p. 105.
— =Chronic, Infective, Summer.= Vol. I, p. 104.
=Anæmia; Pernicious.= Vol. I, p. 375.
=Diphtheria in Calves.= Vol. II, p. 24.
=Ulcerative Stomatitis of Swine.= Vol. II, p. 29.
=Mycotic Stomatitis; Thrush in Sucklings.= Vol. II, p. 36.
=Microbian Tonsilitis in Pigs.= Vol. II, p. 46.
=Diphtheria of Pigeons and Chickens.= Vol. II, p. 67.
=Dysentery of Cattle.= Vol. II, p. 240.
=Infective Catarrhal Enteritis of Birds.= Vol II, p. 254.
=Coccidian Enteritis in Cattle.= Vol. 2, p. 258.
„ „ =Dog.= Vol. II, p. 261.
„ „ =Rabbit.= Vol. II, p. 262.
„ „ =Birds.= Vol. II, p. 263.
=Cerebro-Spinal Meningitis.= Vol. III, p. 118.
=Tubercle and other Infective Diseases of the Vertebræ.= Vol. III, p.
172.
=Parturition Fever= (=Paresis=). Vol. III, p. 299.
=Infectious Conjunctivitis in Herbivora.= Vol. III, p. 368.
=Recurrent Ophthalmia.= Vol. III, p. 404.
=Contagious Pustular Dermatitis in the Horse.= Vol. III, p. 505.
=Rachitis.= Vol. III, p. 565.
=Rarefying Osteitis.= Vol. III, p. 579.
=Rheumatism.= Vol. III, p. 528.

INDEX.

Abortion and ergot, 371.

Abortion, contagious, 370.

Abscesses, secondary, their seats, 5.

Acute hæmorrhagic toxæmia, 141.

Adynamic catarrhal fever of the horse, 112.

Adynamic pneumonia, 95.

Agglutination test in diagnosis, 457.

Amœba Meleagridis, 388.

Anæmia in dourine, 524.

Anæmia, pernicious, 585.

Anasarca, 141.

Anasarcous toxæmia, 141.

Anthrax, 195.

Anthrax and protozoan cattle fever, 560.

Anthrax, apoplectic, 202, 206.

Anthrax, bacillus, 200.

Anthrax bacillus, vitality, 201.

Anthrax, causes, 197.

Anthrax, definition, 196.

Anthrax, differential diagnosis, 209.

Anthrax, disinfection, 213.

Anthrax, drainage of land, 220.

Anthrax, emphysematous, 181.

Anthrax, external, 203, 206.

Anthrax, forms of, 202.

Anthrax, fulminant, 202, 206.

Anthrax, geographical distribution, 196.

Anthrax, History, 196.

Anthrax, immunity after first attack, 198.

Anthrax, immunization from, 214.

Anthrax, immunization, modes of, 216.

Anthrax, imports restricted, 220.

Anthrax in birds, 208.

Anthrax, incubation, 205.

Anthrax in dogs, 208.

Anthrax, infection atria, 202.

Anthrax in horse, 207.

Anthrax in man, 221.

Anthrax in man, causes, 221.

Anthrax in man, forms, 222.

Anthrax in man, intestinal, 224.

Anthrax in man, lesions, 223.

Anthrax in man, prevention, 226.

Anthrax in man, pulmonary, 226.

Anthrax in man, treatment, 227.

Anthrax in sheep and goats, 207.

Anthrax in swine, 207.

Anthrax, interdiction of sales, 214.

Anthrax, internal, 203.

Anthrax, isolation, 213.

Anthrax, lesions, 203.

Anthrax, mortality, 211.

Anthrax, movement of herds, 213.

Anthrax œdema, 223, 225.

Anthrax, pathogenesis, 198.

Anthrax, prevention, 11.

Anthrax, prevention in animals, 212.

Anthrax, prognosis, 211.

Anthrax symptoms, 205.

Anthrax, synonyms, 196.

Anthrax toxins, 204.

Anthrax, treatment, 221.

Aphtha epizoötica, 316.

Aphthous fever, 316.

Apiosoma bigeminum, 545.

Apoplectiform septicæmia immunization, 397.

Apoplectiform septicæmia in chickens, 393.

Apoplectiform septicæmia, lesions, 394.

Apoplectiform septicæmia, pathogenesis, 396.

Apoplectiform septicæmia, symptoms, 394.

Argentina, Lombriz in, 65.

Arteritis and pyæmia, 4.

Aseptic fever, 8.

Asthenia in chickens, 392.

Asthenia in chickens, bacterium, 392.

Asthenia in chickens, pathogenesis, 392.

Asthenia in chickens, treatment, 393.

Australian tick fever, 543.

Avian and human bacillus of tubercle, Nocard’s experiment, 413.

Azoturia, bacteriology of, 649.

Azoturia in the horse, 649.

Babesia bigeminum, 545.

Bacilli in distemper, 168.

Bacillus anthracis, 200.

Bacillus anthracis emphysematosa, 183.

Bacillus Chauvæi, 183.

Bacillus choleræ suis, 24, 26.

Bacillus gastromycosis ovis, 510.

Bacillus liquefaciens bovis, 603.

Bacillus mallei, 233.

Bacillus of emphysematous anthrax compared with that of anthrax, 184.

Bacillus of emphysematous anthrax, vitality, 185.

Bacillus of malignant œdema, 11, 12.

Bacillus of Nicolaier, 293.

Bacillus of rouget, 20.

Bacillus of septicæmia hæmorrhagica in cattle, 56.

Bacillus of septicæmia hæmorrhagica in cattle, vitality of, 57.

Bacillus of septicæmia hæmorrhagica in sheep, 65, 70.

Bacillus of swine plague, 47.

Bacillus pestis suis, 47.

Bacillus tetani, 293.

Bacillus tetani, as a saprophyte, 294.

Bacillus tetani, toxins of, 295.

Bacillus tuberculosis, 410.

Bacillus tuberculosis, action of disinfectants on, 415.

Bacillus tuberculosis, biology, 411.

Bacillus tuberculosis, evolutionary forms, 412, 413.

Bacillus tuberculosis in diagnosis, 457.

Bacillus tuberculosis in man and cattle, 466.

Bacillus tuberculosis in man and ox, common features, 470.

Bacillus tuberculosis in salted meat, 414.

Bacillus tuberculosis, morphology, 410.

Bacillus tuberculosis of man rendered pathogenic to bird, 469.

Bacillus tuberculosis of man variable in potency, 468.

Bacillus tuberculosis, staining, 411.

Bacillus tuberculosis, vitality, 413.

Bacterium choleræ gallinaceæ, 159.

Bacterium coli commune, 27.

Bacterium of chicken asthenia, 392.

Bacteriology of septicæmia hæmorrhagica in cattle, 55.

Barbone, 55.

Bench show distemper, 181.

Bilious pneumonia, 95.

Blackhead in turkeys, 388.

Blackleg, 181.

Black quarter, 182, 55.

Black water, 543.

Blautong, 516.

Blitz catarrh, 113.

Blood clots, infective, 4.

Blood, relation to pyæmia of microbes and toxins in, 5.

Blue sickness, 23.

Blue tongue in horse, 516.

Bones, tubercle of, 436.

Boöphilus bovis, 548.

Boöphilus bovis as the cause of Texas fever, 548.

Boöphilus, dressing for, 564.

Boöphilus, its destruction on pastures, 564.

Bovine periodic fever, 543.

Bovine pleuro-pneumonia, 599.

Bovine yellow fever, 543.

Bradsot, 508.

Brain, tubercle of, 436.

Braxy, 508.

Braxy, causes, 509.

Braxy, definition, 508.

Braxy, geographical distribution, 508.

Braxy, its bacteriology, 510.

Braxy, lesions, 511.

Braxy, pathogenesis, 510.

Braxy, prevention, 512.

Braxy, symptoms, 511.

Braxy, treatment, 513.

Breeding paralysis, 519.

Brine poisoning of pigs, 39.

Broken buttock, 533.

Bronchitis, infectious stable, 111.

Brustseuche, 95.

Buffalo disease, 55.

Caderas, mal de, 532.

Calcified tubercle, 431.

Canine distemper, 165.

Canine madness, 260.

Carbuncular fever, 23.

Carceag, 573.

Caseated tubercle, 430.

Catarrhal fever, adynamic, 112.

Catarrh, infectious bronchial, in dog, 181.

Cattle lung plague, 598.

Cattle plague, 623.

Cattle plague, accessory causes, 628.

Cattle plague, bacteriology, 627.

Cattle plague, channels of infection, 628.

Cattle plague, definition, 624.

Cattle plague, gastro-intestinal lesions, 630.

Cattle plague, historic notes, 625.

Cattle plague, immunity, 628.

Cattle plague, lesions, 629.

Cattle plague, pathogenesis, 627.

Cattle plague, susceptibility to, 628.

Cattle, pulmonary tuberculosis in, 431.

Cattle tick, 548.

Cattle, ulcerative infection of the limbs in, 74.

Chancrous epizoötic, 519.

Charbon, 196.

Charbon blanc, 141.

Charbon symptomatique, 182.

Chauveau’s experiments on tuberculosis, 409.

Chicken cholera, 158.

Chicken cholera, accessory causes, 160.

Chicken cholera, bacteriology, 159.

Chicken cholera, diagnosis, 163.

Chicken cholera, distribution, 158.

Chicken cholera, history, 158.

Chicken cholera, immunization from, 164.

Chicken cholera, incubation, 161.

Chicken cholera, lesions, 162.

Chicken cholera, losses from, 159.

Chicken cholera, pathogenesis, 161.

Chicken cholera, prevention, 164.

Chicken cholera, prognosis, 163.

Chicken cholera, symptoms, 161.

Chicken cholera, treatment, 165.

Chicken pasteurellosis, 158.

Chicken typhoid, 158.

Cholera suis, 22.

Cimurro, 166.

Cirrhosis of the liver in cattle, enzoötic, 641.

Clavelee, 347.

Cocco-bacilli in distemper, 169.

Cocco-bacillus of contagious pneumonia of the horse, 99.

Cocotte, 113.

Consumption, 399.

Contagious abortion, 369.

Contagious abortion, accessory causes, 370.

Contagious abortion, acquired immunity, 380.

Contagious abortion bacillus of colon group, 377.

Contagious abortion, bacteriology, 376.

Contagious abortion, Bang’s bacillus, 377.

Contagious abortion, casual infections, 374.

Contagious abortion, definition, 370.

Contagious abortion, exclusion, 385.

Contagious abortion, experimental infections, 375.

Contagious abortion, extinction, 386.

Contagious abortion, immune infecting, 382.

Contagious abortion in mares, 384.

Contagious abortion, lesions, 383.

Contagious abortion, micrococcus, 376.

Contagious abortion, pathogenesis, 370.

Contagious abortion, pathology, 376.

Contagions abortion, prevention, 384.

Contagious abortion, symptoms, 383.

Contagious abortion, synonyms, 370, 372.

Contagious abortion, treatment, 384.

Contagious abortion, varieties, 377.

Contagious pleuro-pneumonia, 599.

Contagious pneumonia and influenza, 133–4.

Contagious pneumonia causes, 96.

Contagious pneumonia, convalescents infecting, 97.

Contagious pneumonia, definition, 95.

Contagious pneumonia, history, 96.

Contagious pneumonia in horse, 97.

Contagious pneumonia in horses, 95.

Contagious pneumonia in the horse, bacteriology of, 98.

Contagious pneumonia in the horse, course, 104.

Contagious pneumonia in the horse, diagnosis, 105.

Contagious pneumonia in the horse, immunization against, 110.

Contagious pneumonia in the horse, incubation, 101.

Contagious pneumonia in the horse, lesions, 100.

Contagious pneumonia in the horse, prevention, 106.

Contagious pneumonia in the horse, prognosis, 105.

Contagious pneumonia in the horse, quarantine for, 109.

Contagious pneumonia in the horse, serum therapy of, 111.

Contagious pneumonia in the horse, symptoms, 101.

Contagious pneumonia in the horse, treatment, 106.

Contagious pneumonia less diffusible than influenza, 97.

Cornstalk disease, 55.

Coronet, gangrene of, 76.

Coryza contagiosa equorum, 78.

Coryza gangrenosa, 141.

Cowpox, 340.

Cowpox, causes, 340.

Cowpox, course, 346.

Cowpox, diagnosis, 345.

Cowpox, prognosis, 346.

Cowpox, symptoms, 344.

Cowpox, treatment, 346.

Curtice’s smear for boöphilus, 564.

Cynolyssa, 260.

De Schweinitz, serum therapy in swine plague, 52.

De Schweinitz, serum treatment in hog cholera, 45.

Destruction of red globules, 553.

Diagnosis of septicæmia hæmorrhagica in cattle, 61.

Diagnosis of swine plague, 50.

Diastashemia, 141.

Dikkopziekte, 513.

Diphtheria in pig, 23.

Diplococcus pneumoniæ Contagiosæ Equi, 98.

Disinfection in hog cholera, 42.

Distemper, forms of, 170.

Distemper in dogs and cats, 165.

Distemper in dogs, causes, 167.

Distemper in dogs, cutaneous symptoms, 173.

Distemper in dogs, definition, 166.

Distemper in dogs, digestive symptoms. 173.

Distemper in dogs, eye symptoms, 172.

Distemper in dogs, history, 166.

Distemper in dogs, immunization, 176.

Distemper in dogs, incubation, 171.

Distemper in dogs, lesions, 174.

Distemper in dogs, microbiology of, 168.

Distemper in dogs, nervous symptoms, 174.

Distemper in dogs, pathogenesis, 166.

Distemper in dogs, prevention, 175.

Distemper in dogs, respiratory symptoms, 171.

Distemper in dogs, symptoms, 171.

Distemper in dogs, synonyms, 166.

Distemper in dogs, treatment, 177.

Distemper in young horses, 78.

Distemper, mortality, 170.

Distemper of bench show, 181.

Distemper, prognosis, 171.

Distemper, virulent products in, 170.

Dog ill, 166.

Dog pox, 361.

Dogs, paludism in, 577.

Dourine, 519.

Dourine, abdominal lesions.

Dourine, causes, 520.

Dourine, changes in blood, 524.

Dourine, definition, 519.

Dourine, diagnosis, 528.

Dourine, extinction of, 531.

Dourine, history, 520.

Dourine, history in America, 520.

Dourine in geldings, 520.

Dourine, its primary home, 520.

Dourine, lesions in dog, 525.

Dourine, lesions in horse, 523.

Dourine, lesions in mare, 525.

Dourine, microbiology, 521.

Dourine, nervous lesions, 523.

Dourine, pathogenesis, 519.

Dourine, prevention, 530.

Dourine, prognosis, 528.

Dourine, symptoms, 525.

Dourine, symptoms in ass and mule, 529.

Dourine, symptoms in dog, 529.

Dourine, symptoms in horse, 525.

Dourine, symptoms in mare, 527.

Dourine, symptoms in rabbits, 530.

Dourine, treatment, 530.

Dropsies in malignant œdema, 13.

Dropsy of connective tissue, 141.

Druse, 78.

Dunpaardziekte, 513.

Eczema epizoötica, 316.

Edematous pneumonia, 95.

Embolism and pyæmia, 4, 6.

Emphysematous anthrax, 181.

Emphysematous anthrax, accessory causes, 185.

Emphysematous anthrax, causes, 183.

Emphysematous anthrax, definition, 182.

Emphysematous anthrax, diagnosis, 187.

Emphysematous anthrax, distribution, 182.

Emphysematous anthrax, immunization, 191.

Emphysematous anthrax, incubation, 186.

Emphysematous anthrax, lesions, 187.

Emphysematous anthrax, pathogenesis, 182.

Emphysematous anthrax, prevention, 189.

Emphysematous anthrax, symptoms, 186.

Emphysematous anthrax, synonyms, 182.

Emphysematous anthrax, treatment, 188.

Emprosthotonos, 299.

Entero-hepatitis, amœba of, 388.

Entero-hepatitis, diagnosis, 390.

Entero-hepatitis, lesions, 389.

Entero-hepatitis, prevention, 391.

Entero-hepatitis, symptoms, 389.

Entero-hepatitis, treatment, 391.

Enzoötic abortion, 370.

Epizoötic, 113

Epizoötic abortion, 370.

Epizoötic catarrh, 113.

Epizoötic cellulitis, 113, 129, 140.

Epizoötic paraplegia, 519.

Epizoötic pleuro-pneumonia, 599.

Equine influenza, 112.

Equine syphilis, 519.

Equinia, 231.

Ergot and abortion, 371.

Erysipelas in swine, 23.

Eye, tubercle of, 436.

Farcy, 231.

Farcy in cattle, 257.

Fermentation fever, 8.

Fibroid tubercle, 431.

Fibrosis in tubercle, 431.

Foot and mouth disease, 316.

Foot and mouth disease, bacteriology, 318.

Foot and mouth disease, causes, 317.

Foot and mouth disease, definition, 316.

Foot and mouth disease, diagnosis 321.

Foot and month disease, geographical distribution, 317.

Foot and mouth disease, history, 317.

Foot and mouth disease, infection of man, 321.

Foot and mouth disease in man, prevention, 323.

Foot and mouth disease, mortality, 320.

Foot and mouth disease, pathogenesis, 316.

Foot and mouth disease, prevention, 324.

Foot and mouth disease, prognosis, 320.

Foot and mouth disease, symptoms, 319.

Foot and mouth disease, symptoms in man, 323.

Foot and mouth disease, treatment, 325.

Foot and mouth disease, treatment in man, 324.

Foot and mouth disease, virulent products, 318.

Fowl cholera, 158.

Gangrene in malignant œdema, 13.

Gangrene of coronet in horse, 76.

Garrapata, 551.

Gastro-conjunctivitis, 113.

Gastro-enteric epizoötic, 113.

Gastro-enteritis, infective, in new born, 645.

Gastro-enteritis of new born, bacteriology, 645.

Gastro-enteritis of new born, prevention, 647.

Gastro-mycosis ovis, 508.

Genital catarrh, infectious in rabbits, 367.

Genital tuberculosis, symptoms, 449.

Genito-urinary tubercle, 435.

Gerlach’s experiments on tuberculosis, 409.

Glanders, 230.

Glanders, acute, symptoms of, 236.

Glanders, causes, 232.

Glanders, chronic, symptoms of, 238.

Glanders, cutaneous, symptoms, 239.

Glanders, definition, 231.

Glanders, diagnosis, 239.

Glanders, forms of, 236.

Glanders, geographical distribution, 231.

Glanders in carnivora, 245.

Glanders, infection atria, 235.

Glanders in frog, 245.

Glanders in man, 246.

Glanders in man, causes, 246.

Glanders in man, lesions, 250.

Glanders in man, symptoms, 248.

Glanders in man, treatment, 256.

Glanders in rodents, 244.

Glanders in sheep and goat, 244.

Glanders in swine, 243.

Glanders, latent or occult, 239.

Glanders, lesions of, 241.

Glanders, pathogenesis, 232.

Glanders, prevention, 251.

Glanders, synonyms, 231.

Glanders, treatment, 254.

Gloss-anthrax, 55, 203, 206.

Glossina morsitans, 595.

Goatpox, 360.

“Going light”, 392.

Goose septicæmia, 654.

Gourme, 77.

Grapes, 399.

“Grease”, 237.

Great white plague, 399.

Hæmaphysalis Leachi, 579.

Hæmaphysalis rosea, 552.

Hæmatoblasts and blood globules in pyæmia, 4.

Hæmoglobinæmia, bacteriology of, 649.

Hæmoglobinæmia in the horse, 649.

Hæmoglobinæmia in the horse, antiseptic treatment, 650.

Hæmoglobinæmia, iodine treatment, 650.

Hæmolysis in influenza, 130.

Hæmorrhagic septicæmia in chickens, 656.

Hæmorrhoidal anthrax, 203, 207.

Heart, tubercle of, 433.

Hepatic cirrhosis of cattle, 641.

Hog cholera, 15, 22.

Hog cholera, accessory causes, 28.

Hog cholera, accessory causes, removal of, 37.

Hog cholera and faulty feeding, 30.

Hog cholera and interstate sanitary work, 44.

Hog cholera and state rights, 44.

Hog cholera bacillus, 24.

Hog cholera bacillus and allied organisms, table of, 26–28.

Hog cholera, definition, 22.

Hog cholera, diagnosis of, 35.

Hog cholera, disinfection, 43.

Hog cholera, disseminated by commerce, 41.

Hog cholera, extinction in herds, 44.

Hog cholera, fulminant, 33.

Hog cholera, gastro-intestinal lesions of, 33.

Hog cholera germ, carried by animals, 40.

Hog cholera germ, carried by flies, 40.

Hog cholera germ, exclusion of, 40.

Hog cholera, history, 23.

Hog cholera, immunization, 42.

Hog cholera, incubation, 33.

Hog cholera losses in U. S., 24.

Hog cholera, market restrictions, 43.

Hog cholera, poisoning mistaken for, 30, 31.

Hog cholera, precautions for owner, 42.

Hog cholera, prevention, 37.

Hog cholera restrictions in England, 43.

Hog cholera, serum treatment, 45.

Hog cholera, spread through markets and butcher shops, 31.

Hog cholera, Swine plague and Rouget, table of differential symptoms,
38.

Hog cholera, symptoms, 33.

Hog cholera, symptoms of acute form, 33.

Hog cholera, symptoms of subacute form, 35.

Hog cholera, synonyms, 23.

Hog cholera, therapeutic treatment, 45.

Hog cholera, Widal test in, 36.

Holzkrankheit, 543.

Horse, gangrene of coronet in, 76.

Horse pox, 337.

Horse pox, symptoms, 338.

Horse pox, treatment, 340.

Horse sickness, 513.

Horse sickness, definition, 514.

Horse sickness, forms of, 516.

Horse sickness, from damp, green fodder, 514.

Horse sickness, geographical distribution, 514.

Horse sickness, immunity, 515, 518.

Horse sickness, lesions, 517.

Horse sickness, pathogenesis, 514.

Horse sickness, penicillium of, 515.

Horse sickness, prevention, 518.

Horse sickness, symptoms, 516.

Hydrophobia, 259.

Hydrophobia, diagnosis, 282.

Hydrophobia, symptoms, 280.

Ictero hæmaturia in sheep, 573.

Immunization against apoplectiform septicæmia, 397.

Immunization against hog cholera, 42.

Immunization against sheeppox, 357.

Immunization against strangles, 92.

Immunization against Texas fever, 567.

Immunization, from anthrax, 214.

Immunization from canine distemper, 177.

Immunization from chicken cholera, 164.

Immunization from septicæmia hæmorrhagica of cattle, 62.

Immunization from swine plague, 51.

Immunization in rabies, 285.

Infarction in pyæmia, 6.

Infections, purulent and septic, 1.

Infectious abortion, 370.

Infectious bronchial catarrh in dogs, 181.

Infectious entero-hepatitis in turkeys, 388.

Infectious genital catarrh in rabbits, 367.

Infectious stable bronchitis, 111.

Infectious stomatitis in lambs and kids, 367.

Infectious stomatitis in lambs, causes, 368.

Infectious stomatitis, lesions, 368.

Infectious stomatitis, mortality, 369.

Infectious stomatitis, pathogenesis, 368.

Infectious stomatitis, prevention, 369.

Infectious stomatitis, streptococcus of, 368.

Infectious stomatitis, symptoms, 368.

Infectious stomatitis, treatment, 369.

Infective blood clots, 4.

Infective myelo-meningitis, 500.

Infective ulceration of anus and vulva in cattle, 651.

Inflammatory œdema, 153.

Influenza, accessory causes, 122.

Influenza, as compared with croupous pneumonia, 133.

Influenza, bacteriology, 120.

Influenza, catarrhal symptoms, 125.

Influenza, cocci and cocco-bacilli, 120.

Influenza, complications in, 129.

Influenza, contagion, 116.

Influenza, diagnosis of, 132.

Influenza, diagnostic symptoms, 124.

Influenza, digestive disorder, 127.

Influenza, equine, 112.

Influenza, exudations, 129.

Influenza, gastro-intestinal lesions in, 130, 131.

Influenza, hæmolysis in, 130.

Influenza, history, 114.

Influenza, immunity, 123

Influenza, incubation, 123.

Influenza, inoculations, 120.

Influenza, lesions, 129.

Influenza, leucocytosis in, 130.

Influenza, mortality, 134.

Influenza, nervous symptoms, 128.

Influenza of 1872–3, 115.

Influenza ophthalmic symptoms, 128.

Influenza phenomena as compared with contagious pneumonia, 133.

Influenza, prevention, 139.

Influenza, prognosis, 134.

Influenza, pulmonary lesions in, 131.

Influenza, quarantine for, 139.

Influenza, rheumatoid symptoms, 129.

Influenza, symptoms, 124.

Influenza, thoracic symptoms, 126.

Influenza, treatment, 135.

Inoculation in diagnosis, 457.

Intestinal anthrax in man, 224.

Ixodic anæmia, 543.

Ixodic toxæmia, 500.

Ixodis Algeriensis, 552.

Ixodis annulata, 552.

Ixodis bovis, 548.

Ixodis Dugesii, 548.

Klebs’ experiments on tuberculosis, 409.

La Grippe, 113.

Lambs and kids, infectious stomatitis in, 367.

Laminitis in influenza, 129.

Lesions in hæmorrhagica septicæmia in sheep, 67.

Lesions in septicæmia hæmorrhagica in cattle, 59.

Lesions of swine plague, 49.

Leucocytosis in influenza, 130.

Leucophlegmasia, 141.

Liver, tubercle of, 434.

Lockjaw, 292.

Lombriz, 63.

Louping-ill, 500.

Lungenseuche, 599.

Lung plague, 56.

Lung plague, abortions in, 613.

Lung plague, absent from lands breeding all their cattle, 600.

Lung plague, acute symptoms, 612.

Lung plague and aspergillus, 616.

Lung plague, and bronchitis, 615.

Lung plague and emphysema, 616.

Lung plague, and fibrinous pneumonia, 616.

Lung plague and foreign body in the heart, 616.

Lung plague and hæmorrhagic septicæmia, 616.

Lung plague and infectious pneumonia, 616.

Lung plague and Oldenburg, 601.

Lung plague and pulmonary congestion, 617.

Lung plague, and tuberculosis, 615.

Lung plague and verminous bronchitis, 616.

Lung plague, auscultation in, 613.

Lung plague, bacteriology, 603.

Lung plague, bronchial exudates, 610.

Lung plague, causes, 602.

Lung plague, chronic form, 614.

Lung plague, complex infection, 614.

Lung plague, contagion through the air, 605.

Lung plague, course, 613.

Lung plague definition, 599.

Lung plague, diagnosis, 614.

Lung plague, duration of infection in sequestra, 607.

Lung plague, exclusion of infected things, 618.

Lung plague, extension into new countries, 600.

Lung plague, extensions in autumn, 607.

Lung plague, granular, hepatised lung, 609.

Lung plague, history, 599.

Lung plague, honey combed lung, 609.

Lung plague, immunity of secluded islands, mountains, etc., 602.

Lung plague, immunizing by a first attack, 619.

Lung plague in Atlantic States, 601.

Lung plague in Australia, 602.

Lung plague in Brooklyn, 601.

Lung plague in cattle, 598.

Lung plague, incubation, 610.

Lung plague in Denmark, 600.

Lung plague, individual receptivity, 611.

Lung plague in England, 600.

Lung plague, infarction of lung, 608.

Lung plague, infection by mingling of herds, 605.

Lung plague, infection through active trade, 606.

Lung plague, infection through attendants, 605.

Lung plague, infection through convalescent, 607.

Lung plague, infection through food, 605.

Lung plague, infection through manure, 606.

Lung plague, infection through pastures, 605.

Lung plague, infection through stables, 606.

Lung plague, infection through unfenced places, 605.

Lung plague, infection through watering troughs, 605.

Lung plague, infiltrated lung, 609.

Lung plague in Holland, 600.

Lung plague in Ireland, 600.

Lung plague, injection of sterilized serum subcutem, 621.

Lung plague in Massachusetts, 601.

Lung plague in Mississippi Valley, 601.

Lung plague in New Jersey, 602.

Lung plague in Norway, 600.

Lung plague, inoculation in tail, 620.

Lung plague, inoculation methods, 620.

Lung plague in Schleswig, 601.

Lung plague, insidious onset, 611.

Lung plague in South Africa, 602.

Lung plague in Sweden, 600.

Lung plague in Tasmania and New Zealand, 602.

Lung plague, intravenous inoculation, 621.

Lung plague, laryngeal lesions, 610.

Lung plague, lesions, 608.

Lung plague, limits of admissible immunization, 622.

Lung plague, marbled lung, 608.

Lung plague, measures to extirpate, 618.

Lung plague microbe, Nocard’s culture of, 604.

Lung plague, micrococci and bacilli in, 603.

Lung plague, modes of transmission, 604.

Lung plague, only by infection, 600.

Lung plague, percussion in, 613.

Lung plague, pericardial exudates, 610.

Lung plague, pleural exudates, 609.

Lung plague, prevention, 618.

Lung plague, private control of, 619.

Lung plague, proclivity of breeds, 611.

Lung plague, quarantine for, 618.

Lung plague, recoveries, 613.

Lung plague, refrangent corpuscles in, 603.

Lung plague, sequestra, 608.

Lung plague, stalactite-like bronchia, 609.

Lung plague, suppression in America, 601.

Lung plague, symptoms, 611.

Lung plague, synonyms, 599.

Lung plague, thoracic glands in, 610.

Lung plague, transient cases, 611.

Lung plague, treatment, 617.

Lung plague, varying receptivity, 607.

Lymphangitis epizoötica, 257.

Lymphangitis farcinoides, 257.

Lymphangitis saccharomycotica, 257.

Lymphangitis saccharomycotica, distribution, 257.

Lymphangitis saccharomycotica, pathogenesis, 257.

Lymphangitis saccharomycotica, symptoms, 258.

Lymphangitis saccharomycotica, treatment, 258.

Lymphangitis ulcerosa, 257.

Lymph glands, tubercle of, 437.

Lyssa, 260.

Lytta, 260.

Magenseuche, 624.

Maladie de bois, 543.

Maladie de jeune age, 166.

Maladie des chiens, 166.

Maladie du coit, 519.

Mal de Caderas, 532.

Mal de tete de contagion, 141.

Malignant carbuncle, 196.

Malignant œdema, 11.

Malignant œdema, abscess from small dose, 14.

Malignant œdema, cause, 11.

Malignant œdema, diagnosis, 14.

Malignant œdema, immunization, 14.

Malignant œdema, infection channels, 12.

Malignant œdema, invasion by the intestine, 13.

Malignant œdema, lesions, 13.

Malignant œdema, pathogenesis, 12.

Malignant œdema, prevention, 14.

Malignant œdema, symptoms, 13.

Malignant œdema, treatment, 14.

Malignant œdema with proteus vulgaris or micrococcus, 13.

Malignant protozoan jaundice in dogs, 577.

Malignant pustule, 196.

Malignant vesicle, 223, 224.

Malleinization, 254.

Mallein test, 240.

Malleus, 231.

Malleus gangrenosa, 141.

Mammary tubercle, 435.

Mammary tuberculosis, symptoms, 449.

Measles in swine, 23.

Mexican fever, 543.

Microbes, modified by environment, 467.

Micrococci in distemper, 169.

Micrococcus prodigiosus in malignant œdema, 13.

Milk sickness, 325.

Milk sickness, contagion, 327.

Milk sickness, geographical distribution, 326.

Milk sickness, incubation, 329.

Milk sickness in man, 331.

Milk sickness, lesions, 331.

Milk sickness, prevention, 332.

Milk sickness, symptoms, 329.

Milk sickness, treatment, 332.

Miltzbrand, 196.

Moor ill, 543.

Morbus maculosus, 141.

Muscles, tubercle of, 436.

Nagana, 594.

Nagana, alike on flesh and vegetable food, 597.

Nagana, anæmia in, 596.

Nagana, animals susceptible, 595.

Nagana, attempts at immunization, 597.

Nagana, elephants and zebras immune, 595.

Nagana, eye lesions, 596.

Nagana, inoculation, 595.

Nagana, lesions, 596.

Nagana, muscular wasting and debility, 596.

Nagana, not prevented by surra, 597.

Nagana, œdema in, 596.

Nagana, pigeons and hens immune, 595.

Nagana, prevention, 597.

Nagana, symptoms of, 596.

Nagana, toxins, 597.

Nagana, virulent products, 595.

Nagana, vitality of virus, 595.

Nervous fever, 113.

Nocard’s culture of lung plague microbe, 604.

Œdema mycosis, 513.

Œdema mycosis, causes, 514.

Œdema mycosis, pathogenesis, 514.

Omphalitis, 5.

Opisthotonos, 299.

Orthrotonos, 299.

Osteomyelitis, 5.

Ovination, 357.

Ovination, technique, 358.

Oxygen, used by horse, ox and pig, 39.

Paludism in cattle, 542.

Paludism in dogs, 577.

Paludism in dogs, anæmia in, 577.

Paludism in dogs, geographical distribution, 577.

Paludism in dogs, hæmolysis in, 577.

Paludism in dogs, lesions, 580.

Paludism in dogs, microbiology, 578.

Paludism in dogs, prevention, 580.

Paludism in dogs, symptoms, 579.

Paludism in dogs, treatment, 580.

Paludism in horses, 580.

Paludism in horses, anæmia in, 583.

Paludism in horse, causes, 582.

Paludism in horses, duration, 583.

Paludism in horses, geographical distribution, 581.

Paludism in horses, hæmolysis, 582.

Paludism in horses, icterus in, 583.

Paludism in horses, immunization, 582.

Paludism in horses, lesions, 583.

Paludism in horses, microbiology, 581.

Paludism in fresh horses, mortality, 582.

Paludism in horses, prevention, 583.

Paludism in horses, remissions, 582.

Paludism in horses, symptoms, 582.

Paludism in horses, treatment, 584.

Paludism in horses, vertigo in, 582.

Paludism in sheep, 573.

Paludism in sheep, duration, 576.

Paludism in sheep, geographical distribution, 573.

Paludism in sheep, lesions, 575.

Paludism in sheep, microbiology, 575.

Paludism in sheep, prevention, 576.

Paludism in sheep, symptoms, 576.

Pancreas, tubercle of, 435.

Paralysis of breeding solipeds, 519.

Paraplegia, infections, of solipeds in Europe, 538.

Paraplegia, infectious of solipeds in Maraja, 533.