Chapter XIV: Preface (14)

The chloroform has occasionally to be repeated in tooth-drawing before the operation is completed, especially in cases where several teeth require to be extracted. When this is the case, I always reapply it as soon as the patient begins to show signs of feeling the operation, without waiting till he recovers his consciousness. In many cases, however, a number of teeth are extracted without any repetition of the chloroform; and in the instances in which as many as fifteen, seventeen, or nineteen teeth were extracted at one operation, it was chiefly because the first application of the vapour enabled the dentist to take out such a number, otherwise, in most of these cases, a number of the teeth would have been left for a succeeding operation. It has occasionally happened, however, that the chloroform has required to be repeated, once or twice even, for the extraction of a single stump. When the chloroform is repeated once or twice, it is generally a longer time before the patient is able to leave the dentist’s house. I always request the patients who are operated on at the dentist’s, to drive home, as it is not advisable to walk, or use any exertion for an hour or two after the action of chloroform. Indeed, the patient is usually disinclined for any exertion for twenty minutes or half an hour after the influence of this agent, and sometimes for much longer; although I have seen a patient mount the box of a sort of dog-cart, and drive himself away, within five minutes after having several teeth extracted whilst he was in a state of complete insensibility from chloroform.

I have administered chloroform in a great number of cases for the destruction of the nerves of the teeth. The patient requires to be made as insensible in this operation as in tooth-drawing.

_Secondary Hæmorrhage_ after Operations. The hæmorrhage which occasionally comes on several days after an operation, from sloughing, ulceration, or the non-formation of a coagulum in an artery, is probably as liable to occur now as formerly; but I believe that hæmorrhage, a few hours after an operation, is much less frequent since the practice of narcotism by inhalation. Before this practice, it was extremely common for the patient to faint during an operation, when the bleeding of the smaller arteries stopped, and they escaped the ligature, to break out in hæmorrhage occasionally afterwards; but under the influence of narcotic vapours it is unusual for the patient to faint, and consequently every vessel which is capable of bleeding is tied during the operation.

CHLOROFORM IN PARTURITION.

When the practice of inhalation in midwifery was first introduced by Dr. Simpson, he very naturally adopted the plan which is usually followed in surgical operations, making the patient unconscious at once, and keeping her so to the end of the labour. It was soon found, however, by other practitioners, that this is not necessary; and, indeed, it would not be safe in protracted cases. Drs. Murphy and Rigby were, I believe, amongst the first to state, that relief from pain may often be afforded in obstetric cases, without removing the consciousness of the patient; and I soon observed the same circumstance.[150] Some persons, indeed, have alleged that the pain of labour can always be prevented, without making the patient unconscious of surrounding objects; whilst others have asserted that no relief can be afforded unless unconsciousness be induced. But both these opinions are directly opposed to experience. There are comparatively few cases in which the suffering can be prevented throughout the labour without interfering with consciousness, although there are very many cases in which it can be in this way prevented in the early part of the labour. This difference depends, in some measure, on the constitution of the patient, but chiefly on the severity of the pain to be prevented. It is in accordance with what is observed in medical and surgical cases, that the pain should be removed, in some instances, without abolishing consciousness, and that in other instances it should not; for, in certain cases of neuralgia, the pain is so severe, that no material relief can be obtained by chloroform as long as consciousness is retained; and in surgical operations, although it now and then happens that the minor and concluding parts of an operation, such as tying vessels and introducing sutures, can be performed without pain, whilst the patient is consciously looking on, a free incision in the skin can hardly ever be made, under similar circumstances, without pain.

With regard to the cases of labour in which chloroform may be employed, it will be readily conceded that, in cases where the pain is not greater than the patient is willing to bear cheerfully, there is no occasion to use chloroform; but when the patient is anxious to be spared the pain, I can see no valid objection to the use of this agent, even in the most favourable cases. The benefits arising from chloroform in severe cases of labour are experienced in a lesser degree in favourable cases; and the patient may be fairly allowed to have a voice in this, as in other matters of detail which do not involve the chief results of the case. The determination of the kind of labours in which chloroform should be used, or withheld, is really a matter of not much importance, because, as we pass from cases that are severe and protracted to those which are short and easy, the quantity of chloroform that is used, and the amount of diminution of the common sensibility, and of interference with the mental functions, become so trifling, that very little remains about which to hold a discussion. Indeed, from what I have observed of the continued use of this agent in medical cases, and its use by healthy persons for experiment, I believe that the quantity which is inhaled in a short and easy labour might be continued daily for an indefinite period, without appreciable effect on the health.

The above remarks apply also, in some measure, to the question as to the period of the labour when the exhibition of chloroform should commence; for, in proportion as the pains are feeble, it must be more sparingly administered. The most usual time when the accoucheur and I have determined that the inhalation should be commenced, has been when the os uteri was nearly dilated to its full extent, and the pains were taking on an expulsive character. In many of the cases which I have attended, it has, however, been commenced much earlier; for the suffering caused by the dilating pains in the first stage of labour is often very great, and the chloroform is consequently of the utmost service when employed at this time.

As regards the manner of giving chloroform, I shall first allude to cases not requiring manual or instrumental assistance. In such cases, when it has been determined to resort to inhalation, the moment to begin is at the commencement of a pain; and the chloroform should be intermitted when the uterine contraction subsides, or sooner, if the patient is relieved of her suffering. It is desirable to give the chloroform very gently at first, increasing the quantity a little with each pain, if the patient is not relieved. The practitioner easily finds, with a little attention, the quantity of vapour which it is desirable to give at any stage of the labour, and in each particular case; his object being to relieve the patient without diminishing the strength of the uterine contractions and the auxiliary action of the respiratory muscles, or with diminishing it as little as possible. At first, it is generally necessary to repeat the chloroform at the beginning of each “pain”; but, after a little time, it commonly happens that sufficient effect has been produced to get the patient over one or two uterine contractions without suffering, before it is resumed.

The external evidences of the uterine contractions continue as before, when the patient is rendered unconscious by chloroform; and the muscles of respiration are called freely into play, to assist the action of the uterus in the second stage of labour. The aspect of the patient under these circumstances, is generally that of one who is suppressing the expression of her sufferings; and any relative or friend who comes in, without knowing that chloroform has been given, begins to praise the unconscious patient for her fortitude. On some occasions, indeed, there are groans and cries, as of suffering; but the mind being unconscious of pain, it can hardly be said to exist.

It may be remarked, that complete anæsthesia is never induced in midwifery, unless in some cases of operative delivery. The diminution of common sensibility to a certain extent, together with the diminution or removal of consciousness, suffice to prevent the suffering of the patient during labour; and she never requires to be rendered so insensible as in a surgical operation, when the knife may be used without causing a flinch or a cry. The nerves of common sensation must be allowed to retain their functions to a certain extent during labour; otherwise the assistance of the respiratory muscles, which consists of reflex action, or “motion arising from sensation, without the aid of volition”, would not take place, even if the contractions of the uterus should still continue.

The effects of chloroform on the brain should not be carried during labour beyond what I denominate the second degree of narcotism, or that condition in which the mental functions are diminished, but not altogether suspended, except when the effect of the vapour is associated with natural sleep. The patient under the influence of chloroform to this extent, has no longer a correct consciousness of where she is, and what is occurring around her, but is capable of being aroused to give incoherent answers, if injudiciously questioned. In this state, the patient will sometimes assist the labour by bearing down voluntarily, if requested to do so, and be otherwise obedient to what is said; and by withholding the chloroform for a few minutes, she at any time becomes quite conscious. As a general rule, it is desirable not to hold any conversation whilst the patient is taking chloroform, in order that her mind may not be excited. The plan mentioned above, of giving the chloroform very gently at first, also has a tendency to prevent its causing mental excitement, the patient coming gradually under its effects. In surgical operations, excitement of the mind can nearly always be avoided by carrying the patient pretty rapidly into a state of insensibility, in which the mental functions are necessarily suspended. But in the practice of midwifery, it is not allowable to cause a state of coma or insensibility, except in certain cases of operative delivery, hereafter to be mentioned.

I nearly always employ, in obstetric cases, the inhaler that I use in surgical operations. There is not the same necessity for an accurate means of regulating the proportion of vapour in the air which the patient is breathing during labour, where but a trifling amount of narcotism requires to be induced, as in surgical operations, where a deeper effect is necessary; still I find the inhaler much more convenient of application than a handkerchief, and it contains a supply of chloroform which lasts for some time, thereby saving the trouble of constantly pouring out more. When I do administer chloroform on a handkerchief during parturition, I follow the plan of putting only ten or fifteen minims of chloroform on the handkerchief at one time.

The quantity of chloroform administered during any one pain, never exceeds a very few minims; but the quantity used in the course of a protracted labour is often considerable. I have several times used from four to six ounces; and in one case, at which I was present the greater part of the time, seventeen fluid ounces of chloroform were used with the inhaler, which would produce as much effect as three or four pounds used on a handkerchief. The inhalation was continued with intermissions over a period of thirty-one hours. The patient was unconscious during the greater part of the last five or six hours, but previously to this, her constant complaint was that she had not enough chloroform. She was the wife of a physician, was thirty-seven years of age, and in her first confinement. The membranes ruptured early. The labour was natural, but there was excessive sensibility. The first twenty-six hours of intermitted inhalation were during the first stage of labour.

Chloroform can be best applied when there is an additional medical man, who has not to attend to the ordinary duties of the accoucheur; but it can be given very well by the accoucheur himself, so as to save the greater part of the suffering of labour; although he perhaps cannot always administer it in the perfect way in which he could, if he had no other duties to divide his attention.

It is probable that the use of chloroform has no particular influence over the duration of labour, in the whole number of cases in which it is employed; but individual labours are occasionally either retarded or quickened by it, according to circumstances. In some cases, the chloroform, even when very moderately employed, diminishes both the strength and the duration of the uterine contractions, and prolongs the interval between them, thereby making the labour somewhat longer—a matter of no consequence, however, as the patient is not suffering in any way. In other cases, the inhalation causes the uterine action to become stronger and more regular, by removing the excess of sensibility by which it has been interfered with. This occurs more particularly in the first stage of labour. In some cases, also, the chloroform seems to act as a direct stimulant to the uterine contractions, increasing their force and frequency—a circumstance at which we need not be surprised, when we remember that both opium and brandy, in moderate quantity, often act in the same manner. Chloroform has also the effect of promoting the dilatation of the os uteri in many cases, even when no rigidity exists; and when there is rigidity of the os uteri, the inhalation is of the utmost service, and shortens labour very much. This is the case, also, when there is rigidity of the perineum.

When the forceps have to be applied, it is desirable to make the patient insensible, as if for a surgical operation just before they are applied; and to leave off the chloroform as soon as they are introduced, in order to allow of the uterine action to return, and assist in the delivery. I have always found the action of the uterus return immediately after the forceps were introduced; and where the child was not delivered at once, I have continued the chloroform in sufficient quantity to keep the patient unconscious, whilst allowing the uterine contractions to continue.

I have administered chloroform on nine occasions in which the forceps were applied; in four of the cases, I was sent for in consequence of the operation being required; and in the other five cases, I was in attendance from an early part of the labour, and had administered chloroform more or less for some hours before the forceps were applied. They were applied in three instances by Dr. Murphy, twice by Dr. Ramsbotham, and in the other cases by Drs. Farre, Frere, and Thudichum, and Mr. Peter Marshall.

I have administered chloroform in two cases of craniotomy, both of which were performed by Dr. Murphy, on account of deformity of the pelvis. The amount of chloroform scarcely requires to be increased during this operation beyond what would be given according to the strength of the pains which may be present at the time.

In the operation of turning the child, the mother requires to be made quite insensible, in order that the uterine contraction may be entirely suspended till the legs of the child are brought down, when the inhalation should be discontinued to allow the contraction of the uterus to return. I have notes of six cases of turning the child, in which I have administered chloroform. The first case, which occurred in 1848, was one of natural presentation, in which turning was performed by Dr. Murphy, on account of narrowness of the pelvis, and the impossibility of applying the forceps; the introduction of the hand was difficult on account of want of space, but the uterus offered no resistance. Dr. Murphy has related the case. Three of the other instances of turning were performed by Mr. French, in cases which had been attended by midwives, and the membranes had been ruptured for several hours. The shoulder and part of the chest were in each case pressed down into the pelvis, and the pains were very strong; yet under a full chirurgical dose of chloroform, the child was turned as easily as if the membranes had not been ruptured. In the first of these three cases, the child was dead before the operation commenced. In the other two, it was born alive. In the last case, the membranes had been ruptured for ten hours before the operation was performed. After the child was delivered, there was found to be a second child presenting naturally, but I did not stay to give any more chloroform. The fifth case of turning was performed in a case of elbow presentation by Mr. Peter Marshall. The membranes had been previously ruptured. I administered chloroform, also for Mr. Marshall, in a case where the hand was presenting below the head; he raised it above the head, and as it did not come down again when the pains returned, the labour was allowed to pursue its natural course, and terminated favourably in two or three hours, the child being alive. The chloroform was not continued after the operation was performed. The remaining case of turning was performed by Mr. Tegart, of Jermyn Street. I was in attendance with him from an early stage in the labour, and the operation was performed before the membranes were ruptured.

I administered chloroform, in 1849, in a case in which Dr. Murphy had to make an artificial os uteri. The patient was, of course, made quite insensible as for any other surgical operation; and the vapour was continued afterwards in a modified degree till the labour was completed.

On December 26th, 1850, I was requested by Mr. Cooper, of Moor Street, Soho, to assist him in a case of retention of the placenta. The patient had given birth to a child two hours before, and Mr. Cooper had introduced his hand, but had been unable to bring away the placenta, on account of firm contraction of the uterus in a sort of hour-glass form. On the chloroform being administered, the hand was easily introduced, and the placenta detached, and extracted. There was very little hæmorrhage.

In some of the many cases at which I have met Dr. Cape, premature labour was induced about the eighth month of utero-gestation, by rupturing the membranes, on account of deformity of the pelvis.

In a case attended by Mr. Cantis, the patient was suffering from osteo-sarcoma of the bones about the shoulder. Dr. Ferguson was present during the latter part of the labour. The lady lived a few weeks after her confinement.

A patient, attended in her confinement by Mr. Colambell of Lambeth, in 1853, to whom I gave chloroform, had been long under the care of Dr. Williams with cavities in the lungs. I heard very lately that she was still living.

A patient of Mr. Robert Dunn, to whom I gave chloroform in her confinement, was at the time in a state of insanity.

In one of the patients whom I have attended with Dr. Arthur Farre, there was separation of the recti muscles of the abdomen; which there is no doubt must have taken place gradually during pregnancy. The patient was but twenty years of age, and in her first labour. Quite early in the labour, before the pains were at all strong, Dr. Farre and I observed that the abdomen was of a peculiar form, the uterus projecting very much forwards, whilst there was a slackness in the flanks. The abdominal muscles did not assist the pains at all; and it was probably from this cause that the labour progressed slowly and was terminated at last with the forceps. The recti muscles recovered their position by careful bandaging.

The chloroform has always been left off as soon as the child was born, but a little has been administered again on several occasions during the expulsion of the placenta. The placenta has generally been expelled very soon in the labours in which I have given chloroform; usually in about five minutes. There has hardly ever been uterine hæmorrhage of any amount, except in patients who had suffered from it in previous labours. In a case attended by Mr. Nathaniel Ward, however, there was a slight hæmorrhage before the birth of the child, and about an hour afterwards there was a considerable hæmorrhage which made the patient feel rather faint for some hours. She afterwards went on favourably, however. She was a young woman who had had several children.

A patient, to whom I was recommended by Sir John Forbes, inhaled chloroform in three confinements. She recovered favourably from the two first; but on the third occasion, after going on favourably till the fifth day, she was attacked with puerperal fever, and died on the seventh day from her confinement.

I am not aware that more than one death has been recorded as having occurred from chloroform during labour; and this took place in England, in 1855, when no medical man was present.[151] The patient had inhaled chloroform in America in a previous labour; but her medical man, on the last occasion, who was her particular friend, forbad that agent, and said that if she was determined to have it, he would not attend her. She procured chloroform unknown to him, and a number of scents to put on her handkerchief and hide the odour of it from him. He went to bed in the house, and was not called up till his patient had been dead about an hour. The monthly nurse, who had procured the chloroform for the patient, said that she snored very loudly for an hour after she fell asleep. About five drachms of chloroform were used from the bottle, and the handkerchief from which it was inhaled remained close to the patient’s face till she died. The death seemed to have taken place very slowly, and the monthly nurse was extremely stupid to allow the patient to die. It may also be remarked that the accident would not have taken place except for the medical man’s extreme objection to the use of chloroform.

The chloroform has been occasionally blamed by the friends of patients, or medical men opposed to its use, in cases where patients have died from puerperal convulsions or other causes, so long after the vapour had been left off that it could not be the cause of death. The following case shows how easy it would be to make a mistake with respect to the effects of chloroform. Soon after its introduction, I was requested to administer it to the wife of a medical man who had a great desire for it in her confinement. Mr. Propert was to attend the lady. I was sent for late one evening, but as there were no pains at the time when I arrived, I was requested to go to bed in the house. After a time, I was called by a servant, who told me that the baby was born, and that Mr. Propert was sent for. I found that the birth had been so sudden that the husband, who was in the room, could not get to the bed side before the child was born. Mr. Propert arrived, and I went home, leaving the patient very well. Mr. Propert informed me, that after I left the patient went into such a state of syncope as to make him think she was going to die, and continued so for some time. She ultimately recovered. There was no hæmorrhage or any other cause to account for the faintness, and I understood Mr. Propert to say, that if the patient had inhaled chloroform, he should have blamed it for the condition into which she lapsed.

THE INHALATION OF CHLOROFORM IN MEDICAL CASES.

_Neuralgia._ When the pain of neuralgia is not extremely severe, it may be removed by the inhalation of chloroform without causing unconsciousness; but when it is very severe, it is necessary to make the patient unconscious before the pain is suspended. In some cases of neuralgia of the face, the pain is so severe that the signs of it remain after the patient is rendered unconscious, and only disappear when he is quite insensible; and then, as the insensibility passes off, the hand is raised to the face, and the contortions of the features return before the patient awakes to be aware of his suffering. When the mental branch of the fifth nerve is affected, the paroxysms of pain are accompanied by a motion and smacking of the lips. In a hospital patient I have seen this when he was awake, but in a gentleman only when his consciousness was removed by the chloroform, and before complete insensibility was induced; when awake, he restrained the impulse to this kind of motion of the lips.

In administering chloroform it is desirable to continue it steadily and gradually till the pain is relieved; and if the patient is rendered unconscious before the pain is removed, to continue it till all signs of suffering disappear. After the first inhalation of the vapour, the pain will generally return in a few minutes, but when again subdued, it will not return so quickly; and after it has been suspended a few times by the repetition of the chloroform during the space of an hour or so, the pain is usually removed either permanently or for two or three hours. In some cases I have had to repeat the chloroform occasionally throughout the day, and, on one or two occasions, for two or three days in succession. The chloroform can, in general, only be considered a temporary remedy, and therefore such other medicines should be applied as may be thought advisable.

When I have prescribed chloroform in a liniment, to be applied to the face, the patient has often found out that he obtained more relief by smelling at the liniment than by applying it. Chloroform generally gives great relief, however, when applied locally in neuralgia, either alone or mixed with camphorated spirit; it is advisable to apply it on a piece of lint or blotting paper, which should be covered over with tinfoil, or some other impermeable substance, to prevent the evaporation. It causes about as much heat and uneasiness as a mustard poultice, before it relieves the pain.

_Spasmodic Asthma._ On November 12th, 1850, I administered chloroform in the Hospital for Consumption, at Brompton, to a married woman, aged thirty-five, a patient of Dr. Cursham. She was in a fit of spasmodic asthma, but was the subject also of chronic bronchitis. Twenty minims of chloroform were inhaled from an inhaler. It gave immediate relief, producing a momentary state of unconsciousness, or a state bordering on it. In a few minutes the difficulty of breathing gradually returned, but not to the same extent, and the inhalation was repeated with a like effect. The difficulty of breathing returned less quickly and severely; and after a third inhalation of twenty minims she was completely relieved, and could lie down. The patient had a good night, and was better next day. On the 14th, she had another fit of spasmodic asthma, which was relieved completely by the chloroform in the same manner as the previous one. This patient inhaled extract of stramonium every evening, by a method which will be described further on.

Other cases of spasmodic asthma have been relieved as readily and completely; but in one or two cases, in which the difficulty of breathing seemed to depend on disease of the heart, the relief was not so great; the patient went to sleep, but the breathing remained embarrassed.

_Spasmodic Croup._ I have administered chloroform in seven cases of this complaint. It was recommended in every instance by Dr. Ferguson, and all the cases ended in recovery. The children were from eight months to two years of age; the majority being about a year. I always gave enough chloroform to cause a state of unconsciousness, for which a few minims suffices in a young child, and when the effect passed off, or nearly so, I repeated the dose. I generally gave five or six doses in the course of about half an hour, after which the child would often sleep for two or three hours. In the milder cases it was repeated once a day; but in the more severe cases it was continued, in the above manner, twice a day. I administered it to a patient of Dr. Van Oven, respecting whom Dr. Ferguson had been consulted, for fifteen days, twice every day, excepting the last three days. This child was very ill when the treatment was first commenced, having a severe fit of spasmodic breathing every five minutes. When the chloroform is given during the spasm, it is desirable to give it very cautiously.

Mr. W. J. H. Cox read a paper on the treatment of laryngismus stridulus, with chloroform, at the London Medical Society, in 1850. He had entrusted the administration of it to the mother or nurse, and directed it to be given whenever the spasmodic breathing should come on. I am inclined to think that this would be the best way of giving it, if one could be quite sure of the intelligence of the party to whom it was entrusted.

_Hooping-Cough._ I have only administered chloroform in two cases of this complaint. It was recommended in both cases by Dr. Ferguson. One of the children was extremely ill of bronchitis, and it died. The other child recovered, but the chloroform was not continued. I am not aware that chloroform has had any fair trial in hooping-cough. It should be given whenever a fit of coughing comes on.

_Infantile Convulsions._ I have administered chloroform in two cases of this disease, with the effect of relieving the convulsions, but the children died. They were both extremely ill before the chloroform was administered. One was the patient of Mr. Walter Bryant, and Dr. Seth Thompson was consulted about it. A case has been related by Dr. Simpson of Edinburgh, in which the chloroform was continued for a day or two, and in which the infant recovered.

_Delirium cum Tremore._[152] Some cases have been related in the medical journals, in which this complaint was treated successfully by chloroform alone; but I prefer to use this agent only as an adjunct to the treatment by opium. Sometimes the patient is so violent and suspicious that he cannot be made to take opium; but it is much easier to make a person breathe a medicine, than swallow one. It is only necessary to hold a patient, and to apply the chloroform near his face, and he is obliged to breathe it, and as the effect of it subsides, he recovers the power of swallowing before his delirium returns; for whilst he is still unconscious, he will swallow whatever is poured into his throat. Opium can be administered, and the chloroform can be repeated occasionally so as to keep him asleep for an hour or two till the opium takes effect and prolongs the sleep. It is a great advantage of chloroform that the delirium may be subdued in a few minutes by it, and can be kept away till opium takes effect.

In certain cases of delirium cum tremore, such a quantity of opium is taken without procuring sleep, that the medical attendant has, what I believe to be, a well-grounded fear of giving more. A patient whom I saw with Mr. Peter Marshall, in April 1850, had taken ten fluid drachms of laudanum and two grains of acetate of morphia, within twenty-four hours of my seeing him, without any sleep being procured. He was put to sleep immediately by chloroform, which was repeated on the following day. The patient got quite well in a few days.

In December 1851, I saw a patient who had had no sleep for four days, except three intervals of a quarter of an hour each, although a great deal of opium had been given. He was very violent; and for the last twelve hours had spat out all the medicine that was given to him; his pulse was small and very rapid. He was made insensible in a few minutes, and the chloroform was repeated, at intervals, for half an hour, so as to keep him unconscious. Fifty minims of tincture of opium were given in one of the intervals. I waited an hour and a quarter after the chloroform was discontinued; the patient was still sleeping, and his pulse was less frequent. I learnt that when he awoke he was quite free from delirium, and he was well in a few days.

_Delirium in Fever._ In November 1857, I administered chloroform to a youth of seventeen, who had been ill of typhoid fever for sixteen days. He had been in a state of constant delirium for upwards of forty-eight hours without having the least sleep, although he had had tincture of opium in divided doses to the extent of forty-five minims, and had taken a tablespoonful of wine every four hours. The chloroform was continued gently for half an hour; he slept for an hour afterwards, and at intervals during the night. He was a little better in the morning; and the delirium was not again so violent as it had been. He died on the nineteenth day of the fever, from a recurrence of diarrhœa.

Dr. Fairbrother, of Bristol, gave small doses of chloroform by inhalation, with the best effects, in a case of typhus fever, in the Bristol Infirmary. The patient was delirious and worn out for want of sleep, her life being in fact despaired of. She inhaled the chloroform occasionally for several days, sleep being always procured when it was applied, and she recovered without any other medicine.[153]

_Hydrocephalus._ I administered chloroform on two occasions, for half an hour at a time, to a child, seven years old, when delirious and screaming violently, in this complaint. The child was much relieved by the inhalation, but it died on the fourteenth day of the disease.

_Tetanus._ I have notes of three cases of tetanus in which I have administered chloroform. The first was a patient of the late Mr. Keate, in St. George’s Hospital, in February 1849. It was a girl, fourteen years old, who had received some severe burns in the face and various parts of the body, a fortnight previously. Four days before inhaling the chloroform, she was attacked with symptoms resembling those of chorea, but for the last two days the complaint was recognised to be tetanus. There was rigidity of the spine and jaws, and of one arm, which was flexed. Spasms came on every minute or two, affecting, more particularly, the head and the arm. I commenced to give chloroform very gently at four in the afternoon. It prevented the spasm before consciousness was quite removed. Whenever the spasm offered to return, the inhalation was repeated with the effect of stopping it. The chloroform was continued till half-past five, with the effect of keeping the spasm away; and the patient took some drink during this time, better than she had done previously. I saw the child again at eight o’clock in the evening, and found that the spasms had returned soon after I left, and had continued as before. The chloroform was given again at intervals for an hour and a half, with the effect of keeping away the spasms, and inducing sleep; but I found that the child was getting weaker, and would die even if the spasm was entirely prevented. She died at a quarter past eight the following morning. There was no inspection of the body.

The next case was a patient of Mr. Propert, a boy, ten years of age, who had suffered from sloughing of the skin of the inferior extremities. The tetanus came on during the healing process, whilst the greater part of both extremities was in a state of ulceration, and covered with healthy granulations. The patient was in a very irritable and feeble state, and his pulse was 150 in the minute. He was made insensible, and the chloroform was repeated twice in the space of half an hour. No relaxation of the muscles of the jaws was produced, although the effect of the chloroform was carried as far as seemed safe in such a subject. He died twelve hours afterwards.

I administered chloroform lately to a patient of Mr. Salmon in St. Mark’s Hospital. He underwent an operation by ligature for prolapsus ani and hæmorrhoids on March 1st; on March 5th tetanus commenced, and on March 7th chloroform was administered whilst Mr. Salmon removed some sloughs from the anus; and it was repeated occasionally afterwards. The patient was a man, fifty-two years of age; he was the subject of kidney disease, and the tetanus was extremely severe. He had had four doses, each containing a fluid drachm of laudanum, between the time when the tetanus commenced and his inhaling the chloroform. His pupils were contracted, and he was made insensible by an extremely small quantity of chloroform. He was, in fact, very much under the influence of opium, although the spasm of the tetanus prevented his sleeping.

Chloroform affords great relief to the patient affected with tetanus, and it probably increases the prospect of recovery in cases which are not too severe and acute.

_Epilepsy._ Dr. Todd at one time had chloroform administered by inhalation, in King’s College Hospital, to the extent of causing insensibility, at stated intervals, in cases of epilepsy, and he thought with advantage. I have frequently administered chloroform for surgical operations to patients who were subject to epilepsy, and have very rarely found it produce any approach to a fit.

In July 1850, I administered chloroform to a boy, seven years old, in an epileptic fit, which had lasted about an hour when the inhalation was commenced. He had had fits previously, the last of which had occurred a year before, but none of them had lasted so long as the existing one. He had eaten nine new potatoes for his dinner, at one o’clock, and the fit came on about eight. I found the abdomen swollen and very tympanitic. There was constant convulsive motion of the right arm, and of the neck; the latter drawing the head to the right side. The mouth was also drawn to the right at each convulsive motion. The chloroform was given by putting a few minims at a time on a handkerchief, and holding it to the mouth and nostrils. It caused immediate cessation of the convulsions every time it was applied. The convulsions, however, returned again in a minute or two. In the intervals that he was partially under the influence of the vapour, he breathed easily without stertor. The convulsions became gradually less severe, and ceased entirely ten or fifteen minutes after the commencement of the inhalation.

_Puerperal Convulsions_. I have not been called to any case of this complaint since chloroform has been in use; but some cases have been related in the medical journals in which the inhalation of chloroform has been employed with a favourable result. One case is related by Mr. Henry Rudge, of Leominster.[154] When the chloroform was administered, the patient was in violent convulsions which came on in frequently succeeding fits. The os uteri was dilated, and the head presenting. The pains were entirely arrested. The chloroform was administered by twenty minims, at intervals, on a folded handkerchief. The convulsions, after a few inhalations, entirely ceased, and Mr. Rudge extracted the child without difficulty. There was another child with the head presenting: it was delivered with the forceps. The placenta was delivered with the hand on account of smart hæmorrhage. There was only one attack of convulsions after delivery, and the patient recovered favourably. It was her first labour, and her age was twenty-three years.

A case of puerperal convulsions was related by Mr. Andrew Bolton to the Newcastle and Gateshead Pathological Society.[155] His patient, aged twenty-two, was at the full period of her first pregnancy. The os uteri was high, slightly dilated, and extremely rigid. She was treated at first by blood-letting, and full doses of morphia. Mr. Bolton says: “As her condition appeared hopeless should the paroxysms continue, chloroform was administered on a piece of linen, in half-drachm doses, and its full effects kept up for three hours. At two P.M., there was a slight return of convulsion; skin warm and perspiring; the os uteri was found steadily dilating; and from her uneasy movements, it was apparent that uterine action had begun.

“Half-past three. The membranes were ruptured; and brisk uterine action ensuing, a dead child was expelled, immediately followed by the placenta. She regained her senses during the expulsive efforts, but appeared entirely ignorant of her previous condition. Recovery followed without any bad symptom.

“In conclusion, I would remark, that the convulsions were in no measure mitigated by the depletion, which was carried to the utmost; nor was there any yielding of the os uteri until the chloroform was inhaled.”

The urine was not examined in either of the above cases, and it is not stated that œdema was present.

_Hysterical Paralysis and Contractions._ In December 1851, I administered chloroform in Charing Cross Hospital to a young woman about twenty-five, a patient of Dr. Chowne. She kept her left knee in a semiflexed position, and would not allow it to be moved. She had been in bed in the hospital for two months. She inhaled the chloroform reluctantly, and, after becoming unconscious, she breathed and sobbed in a hysterical manner. When insensible, the limb went down flat on the bed, the knee being quite movable. A straight splint was applied, and the limb was secured to it with bandages. I was informed that in a few days she contrived to get her leg bent again. She was the domestic servant of a nobleman. It was evident that there was nothing the matter with her limb, and that it was only influenced by her volition, which was perverted by the hysteria under which she was labouring.

In November, in the same year, I administered chloroform in the same hospital to another patient of Dr. Chowne, whose case was more obscure and complicated. The patient was a woman, aged thirty-three, who represented that for several months she had been unable to open her mouth, or to speak, and that she had, for the same length of time, been paralyzed in the left arm and leg. The affection, it was said, came on suddenly, in a kind of fit, which was followed by unconsciousness for three or four weeks. It was also said, that she had one or two fits the previous year, after which she was unconscious for a long time. The patient was quite conscious before inhaling the chloroform, and replied to questions by nodding or shaking the head, or by writing on a slate. She was unmarried, and had not menstruated for some months past. The chloroform was administered with a view to ascertain whether or not she was feigning. On first becoming unconscious, the patient breathed in a sobbing and hysterical manner. The chloroform was given very gradually; and as she became more affected, there were some struggling and rigidity, when the right arm and leg were moved about a good deal. The left arm and leg were also distinctly moved, but not above a tenth part as much as the extremities of the opposite side. When the patient was quite insensible, the limbs being relaxed, the pupils turned upwards, and the conjunctiva insensible, attention was turned to the jaws, which were still firmly closed, but they were opened by using a moderate degree of force with the fingers. The effect of the chloroform having been allowed in a great measure to subside, it was again administered, when the movements of the limbs recurred, and there was the same difference between the motion of the right side and that of the left, as before. When I left the patient, more than half an hour after the chloroform was discontinued, she had not opened her eyes or answered questions; and she did not do either for six days. I saw her five days after the chloroform. The pulse was very rapid on my first going to the bedside, but its frequency subsided in a few minutes. On my raising the eyelid, she turned her eye about, as if endeavouring to hide the pupil under the lid. On the following day she answered questions by nodding and writing on a slate, and was, in other respects, the same as before inhaling the chloroform.

The great difference in the amount of motion in the limbs of this patient, under the influence of chloroform, showed that the paralysis of the left side was not a mere pretence. It is, indeed, possible that the absence of motion in the limbs of the left side, for several months, would cause them to move less than the opposite ones during the action of chloroform; but it is not to be supposed that the patient would keep these limbs in one posture during the night, and when no one was present, without ever moving them, unless she herself believed that they were paralyzed. I looked on the woman as a sick person, and not a mere impostor; for although she appeared to exaggerate her symptoms, and to have a good deal of pretence and affectation, this circumstance arose, no doubt, from her complaint.

In April 1853, I administered chloroform four times to a patient of Dr. Arthur Farre, a girl of fifteen years of age, who was affected with a contraction of the flexor muscles of the left thigh and leg, of the muscles which bend the body to the left side, and those which bend and turn the head to the same side, in consequence of which the leg was drawn up, and the body and head were curved greatly to the left side. The contraction of the muscles had lasted for several weeks, but she had been ill for a much longer period, her illness having commenced with a fever. She took an extremely small quantity of nourishment, and was very thin. Her bowels were moved with difficulty. The pulse was very feeble and small, and there was a tendency to coldness of the surface. An eminent surgeon in the provinces had expressed his opinion that the distortion of the limbs and trunk was a feigned disorder; but the action of the chloroform proved that he was altogether in error. The muscles became completely relaxed when the patient was quite insensible, and the limbs and trunk and head could be readily moved into any position; but as the effects of the chloroform subsided, the deformity returned on each occasion before the patient recovered her consciousness. Neither the chloroform nor any other measures were of any service, and Dr. Farre informed me that the patient died a few weeks after I saw her.

_Mania._ I have been informed of several cases in which chloroform has been administered in acute mania, with the effect of calming the patient and procuring sleep. I have administered it in two cases with the same temporary advantage. In one of the cases, the patient was persuaded to inhale it; in the other, he had to be held by three keepers till he was unconscious. An eminent and well-known scientific man, who became insane some years ago, refused to take food. It was found that after being made unconscious by chloroform, he would take a meal just as he recovered from its effects, and the chloroform was given before every meal for a long time.

_Spasmodic Pain._ In August 1851, I administered chloroform to a woman who was labouring under a severe paroxysm of spasmodic pain in the abdomen. The pain was completely removed, without altogether causing unconsciousness. An opiate was given to prevent the pain from returning.

I have not had the opportunity of administering chloroform during the passage of calculi down the ureters, or of gall-stones; but there can be no doubt that it would be of the greatest service in such cases. If Dr. Griffin had been provided with chloroform when he attended the late Mr. Augustus Stafford with an attack of gall-stones,[156] he would have been able to relieve his patient in five minutes, instead of taking two or three hours to produce relief by opium. There would have been no occasion for the venesection, which was carried to thirty ounces. And at the end of the attack, on Dr. Griffin leaving his patient for the night, if chloroform had been employed, he would have left him without any appreciable amount of the narcotic in his system. As it was, however, he left him with a quantity of opium unabsorbed from the alimentary canal. The bandage got displaced from the arm; there was an additional hæmorrhage, the opium became absorbed more quickly, and a dangerous state of narcotism was induced.

_Frequent and long continued Use of Chloroform._ Many patients have inhaled this agent hundreds of times, and it continued to produce insensibility as readily as at first. The dose does not require to be increased on account of its long use. I was informed of the case of a lady who was affected with a painful cancer, and was attended by the late Mr. Keate and Mr. Henry Charles Johnson. She inhaled chloroform at frequent intervals, by day and night, for a very long time, consuming three or four ounces in the twenty-four hours.

In November 1851, a surgeon in the north of England wrote to me respecting one of his patients, a lady, who had inhaled a great deal of chloroform, on account of neuralgia of the uterus. He said that, during that year, and principally within the last six months, she had inhaled at least two hundred ounces; that she often inhaled as much as three ounces in a day; and that it seemed to have produced very little effect on her general health, except that she seemed to be more susceptible of pain. He said that he had reluctantly yielded to the entreaties of his patient to administer it so often, and he wished for my opinion respecting the propriety of continuing its use, and what effect it would be likely to produce.

I advised that the chloroform should be continued as long as the severity of the pain rendered it necessary; and expressed my opinion, that it would produce as little ultimate effect as any other narcotic which might be used to relieve the pain. I saw the surgeon in September of the following year. He informed me that the chloroform was continued for some time after he had written to me; but that his patient had recovered from her complaint, and had left off the chloroform, and was in good health.

Mr. Garner, of Stoke-upon-Trent, has related the case of a lady, affected with neuralgia, who inhaled sixty-two ounces of chloroform from her handkerchief, in twelve days.[157]

SULPHURIC ETHER, OR ETHER.

_History and Composition._ “This liquid is first described by Valerius Cordus, in 1540, under the name of _oleum vitrioli dulce_. The term _ether_ was applied to it a hundred and ninety years afterwards by Frobenius, who, in a paper in the _Philosophical Transactions_, described its singular properties; at the end of this paper is a note by Godfrey Hankwitz, Mr. Boyle’s operator, mentioning the experiments that had been made upon it by Boyle and by Newton.”[158]

The present chemical name of ether, or sulphuric ether, is oxide of ethyle. It consists of four atoms carbon, five atoms hydrogen, and one atom oxygen. Its atomic number is consequently 37.

The usual way of making ether, is to distil common alcohol (the hydrated oxide of ethyle) with sulphuric acid.

_Chemical and physical Properties._ Ether is a clear, colourless liquid, of the specific gravity of 0·715 at 68°. It boils at 96° Fahr.; and the specific gravity of its vapour is 2·565. It is soluble, in all proportions, in alcohol, and it is soluble in nine parts, by measure, of water. Water is also soluble in nine parts, by measure, of ether, so that after ether has been agitated with water, it retains one-tenth of its volume of that fluid. Ether is very inflammable, and, as it yields its vapour very freely, great care is required in pouring it out by artificial light. Its vapour is also very explosive when mixed, in certain proportions, with atmospheric air.